Heat shock proteins offer clues to reversing dementia in stressed cells

A specific type of heat shock protein was found to reverse the protein misfolding associated with several neurodegenerative diseases

Researchers investigating the effects of stress on accumulations of toxic brain proteins linked with dementia have discovered a surprisingly counter-intuitive mechanism. A specific cellular stress response involving heat shock proteins has been found to reverse the build-up of these toxic proteins and future research will now look for a way to therapeutically trigger this mechanism.

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siRNA therapy shows promise for reducing genetic heart disease risk

In phase 1 trials, an experimental siRNA therapy has shown promise for reducing levels of a lipoprotein associated with a higher risk of premature heart disease. The treatment could help fight a form of the disease that can’t currently be treated throu… Continue reading siRNA therapy shows promise for reducing genetic heart disease risk

Surprising gut protein discovery is new target for constipation treatment

Researchers in Australia have discovered that a touch-sensitive protein normally found in skin is also located in the gut. There, it seems to sense the presence of food and triggers contractions to push it along, while reduced levels of this protein ma… Continue reading Surprising gut protein discovery is new target for constipation treatment

Genetic study reveals causal link between blood type and COVID severity

The large genetic study has affirmed prior observations linking persons with type A blood to increased risk of severe COVID-19

Very early in the pandemic doctors began tracking the association between COVID-19 disease severity and a patient’s blood type. Now researchers have validated those early observations, finding several blood proteins are causally linked to an increased risk of hospitalization and death from COVID-19.

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Protein tweak makes CRISPR gene editing 4,000 times less error-prone

The CRISPR gene-editing system is a powerful tool that could revolutionize medicine and other sciences, but unfortunately it has a tendency to make edits to the wrong sections of DNA. Now, researchers at the University of Texas at Austin have identifie… Continue reading Protein tweak makes CRISPR gene editing 4,000 times less error-prone

Promising new drug target to treat diabetes and other metabolic diseases

A new preclinical study has demonstrated how an experimental drug can treat type 2 diabetes by increasing the expression of a recently discovered protein found to influence insulin signaling in cells. Across several mouse studies, the research shows th… Continue reading Promising new drug target to treat diabetes and other metabolic diseases

Restoring a deficient “motor” protein could improve fertility success

The leading cause of miscarriage is that human eggs are surprisingly bad at managing the number of chromosomes in them. But now, researchers at the Max Planck Institute have identified a motor protein that helps this process function smoothly, leading … Continue reading Restoring a deficient “motor” protein could improve fertility success

Artificial muscles made of human proteins make for better implants

Researchers have developed a new type of artificial muscle that’s entirely made out of natural proteins. Responding to changes in its environment allows the muscle to flex on demand, which could make it useful for implants, prosthetics or robotics.Cont… Continue reading Artificial muscles made of human proteins make for better implants