One-off gene therapy for rare immune disease still effective 10 years later

A long-term follow-up study tracking a group of children who received experimental gene therapy as part of an early-stage clinical trial is reporting the treatment is safe and effective up to 10 years later. The research offers rare insight into the lo… Continue reading One-off gene therapy for rare immune disease still effective 10 years later

Viral infections in teenagers linked to later onset of multiple sclerosis

It is hypothesized a severe viral infection in adolescence can trigger a cascade of neuroinflammation leading to the onset of neurological disease years, or even decades, later

A pair of new studies are building on a growing hypothesis that the neurological disease multiple sclerosis (MS) can be triggered by viral infections in a person’s teenage years. The research indicates serious adolescent infections such as glandular fever are associated with higher rates of MS diagnoses, and concerns are being raised as to whether the current COVID-19 pandemic could lead to a surge in MS cases in the future.

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Missing link between severe COVID-19 and Alzheimer’s disease discovered

The gene variant plays a role in heightened inflammatory responses influencing both Alzheimer's disease and severe COVID-19

Early in the pandemic researchers saw disproportionately high rates of dementia patients suffering from severe COVID-19. A common hypothesis was that memory impairments associated with neurodegeneration affect a person’s ability to consistently follow infection control measures such as social distancing and mask wearing. But a new study led by scientists from University College London is proposing a key gene variant, known to heighten one’s risk for Alzheimer’s, stimulates the body’s inflammatory responses and can lead to greater susceptibility to severe COVID-19.

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Scientists stumble on rheumatoid arthritis vaccine with huge potential

Researchers from the University of Toledo have discovered a prospective new treatment for rheumatoid arthritis. The vaccine-based treatment strategy proved successful in preliminary animal studies and the researchers are looking to conduct more clinica… Continue reading Scientists stumble on rheumatoid arthritis vaccine with huge potential

New discovery reveals direct link between opioids and gut inflammation

Intriguing new preclinical research from a team of Japanese scientists has found targeting opioid receptors in the gut could be a new treatment for inflammatory bowel disease. The research builds on early evidence showing a relationship between opioids… Continue reading New discovery reveals direct link between opioids and gut inflammation

“Reverse vaccine” trains immune system not to attack beneficial drugs

The immune system is a powerful weapon protecting us from dangerous infection, but sometimes it can get a little overzealous and attack things that are trying to help us. A new preclinical treatment could one day help, using a kind of “reverse vaccine”… Continue reading “Reverse vaccine” trains immune system not to attack beneficial drugs

FDA panel limits COVID booster recommendation to elderly, high-risk

An advisory panel to the US Food and Drug Administration (FDA) has overwhelmingly voted against recommending a broad COVID-19 vaccine booster program for all American adults at this time. Instead, the panel unanimously recommended boosters for those in… Continue reading FDA panel limits COVID booster recommendation to elderly, high-risk

Low-dose radiation heats up “cold” tumors for easier targeting

There are many reasons different cancer treatments don’t have the intended consequences and the disease is able to prosper despite our best efforts. One example is a tumor that contains barely any immune cells, which renders immunotherapy cancer treatm… Continue reading Low-dose radiation heats up “cold” tumors for easier targeting

Clues of link between neurodegeneration and herpes virus infections

New research presents a novel mechanism that could help explain how viral infections lead to neurodegenerative disease

A new study published in the journal Nature Communications is suggesting a novel causal link between neurodegenerative diseases such as Alzheimer’s and infection with the herpesvirus. The preclinical research indicates a deficiency in a key protein allows the virus to trigger neuronal damage.

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Experts argue COVID-19 vaccine boosters should be delayed

A new article published in The Lancet is arguing against broadly administering COVID-19 vaccine booster shots at this point in time. The article is co-authored by two of the US Food and Drug Administration’s top vaccine advisors, both of whom recently … Continue reading Experts argue COVID-19 vaccine boosters should be delayed