Collaborate Disseminate
Effective targeted treatment of multiple sclerosis (MS) and even the repair of damaged nerves caused by the disease could soon be within grasp, thanks to yet another breakthrough in the field of small molecule drug research.Continue ReadingCategory: Me… Continue reading MS drug to treat and repair nerve damage is edging closer to reality
A new study has found that using biologic therapy to reduce lung inflammation enabled 92% of people with severe asthma to reduce their dose of daily inhaled steroid without exacerbating their symptoms. The findings may mean that severe asthmatics can minimize the risk of adverse effects associated with long-term steroid use.
Tags: Asthma, BioLogic, Inflammatory, King’s College London
Continue reading Biologic therapy shown to reduce steroid use in 92% of severe asthmatics
New research has revealed how genetic changes in a specialized population of brain cells called microglia contribute to neuroinflammation and, in turn, to Alzheimer’s disease. The findings could lead to more effective, targeted therapeutics.
Tags: Alzheimer’s Disease, Brain, Inflammatory, Genetics, Brigham and Women’s Hospital
Continue reading Brain cell gene changes linked to neuroinflammation seen in Alzheimer’s
A first-of-its-kind study has identified overactive inflammation and loss of critical protective mechanisms in the brain as potential contributors to suicide risk. The findings could lead to the use of anti-inflammatory medications as a way of reducing… Continue reading Overactive inflammation in the brain linked to increased suicide risk
Short-lived, acute pain is a normal response to an injury and will steadily diminish as inflammation subsides. For some, however, this kind of pain develops into a chronic condition that persists for more than six months. Scientists have had little und… Continue reading Vitamin B3 may give cells the boost they need to reverse chronic pain
Researchers have found that when used on monkeys, an experimental drug slowed the process that leads the tau protein to aggregate into neuron-damaging tangles commonly seen in Alzheimer’s disease and improved the animals’ cognitive functioning. The next step is to develop a drug that can be used in humans.
Tags: Alzheimer’s Disease, Inflammatory, Aging, Yale
Continue reading Drug slows tau’s transformation into toxic tangles seen in Alzheimer’s
There are a lot of research eyes on the development of Polo-like kinase 1 (PLK1) inhibitors for cancer treatment right now, with several drugs currently in clinical trials and at least one in late-stage Phase III testing. But University of Cambridge sc… Continue reading Promising cancer drug may effectively treat gout and heart disease
Researchers investigating the genetics underlying the airway inflammation seen in severe asthma have, for the first time, discovered that proteins that bind to RNA are dysregulated, and drive changes in gene expression in the cells that line the airways.
Tags: RNA, Asthma, Inflammatory, King’s College London
Continue reading RNA-binding proteins discovered to be key to severe asthma
A new study has found that methotrexate, a widely available and affordable drug that’s usually prescribed as a first-line treatment for rheumatoid arthritis, is effective at reducing the pain and stiffness suffered by people with hand osteoarthritis. U… Continue reading Hand osteoarthritis symptoms relieved by an affordable existing drug
New research from a team at the University of Maryland School of Medicine (UMSOM) has for the first time shown how inflammation in early childhood can affect brain development and contribute to the risk of autism spectrum disorders (ASD) and schizophre… Continue reading How inflammation in early childhood can lead to autism and schizophrenia