Early signs of dementia can be detected by tracking driving behaviors

Researchers have developed models that could predict mild cognitive impairment and dementia with 88 percent accuracy

A fascinating new study from a team of US researchers has used machine learning techniques to develop algorithms that can analyze naturalistic driving data and detect mild cognitive impairment and dementia in a driver. The work is still in the preliminary stages, however, the researchers claim it could be possible in the future to detect early signs of dementia using either a smartphone app or devices incorporated into car software systems.

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High blood pressure suggested as link between diabetes and dementia

New research has found diabetics who go on to develop dementia display higher blood pressure for years before cognitive decline appears, compared to diabetics who don't develop dementia

Researchers have long detected higher rates of dementia in people with type 2 diabetes. New findings from Imperial College London are offering clues to why that may be the case, indicating that cardiometabolic factors associated with diabetes, such as increased blood pressure, could be contributing to the development of dementia.

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Novel drug rejuvenates cellular cleaning to reverse Alzheimer’s in mice

An artist's impression of tau tangles taking hold in the brain, which are considered one of the drivers of Alzheimer's disease

A key focus for medical scientists working to prevent or potentially treat Alzheimer’s is coming up with ways to avoid the buildup of toxic proteins in the brain, which could include the use of ultrasound or maybe even regular deep sleep. A team at the Albert Einstein College of Medicine has uncovered another promising pathway, discovering that an experimental drug can supercharge a natural cellular cleaning mechanism to rid mice of these unwanted waste products, and reverse key symptoms of the disease.

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Seven surprising ways exercise can boost human health

We all know exercise is good for us, but science continues to reveal new benefits to getting moving

If you are partaking in regular bouts of exercise, you can expect to experience a range of benefits, like the burning of excess fat, lower risk of heart trouble and a healthier state of mind. Recently, however, scientific studies have started to shine a light on how regular physical activity can benefit human health in more subtle ways, some of which you might not expect. Let’s take a look at some interesting examples.

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Short sleep durations in midlife linked to dementia later in life

A long-term study found persistent sleep durations of less than six hours in middle age were linked with a 30-percent increased risk of developing dementia later in life

A new long-term observational study is reporting a link between short sleep durations of under six hours in midlife and an increased risk of dementia in old age. The research cannot offer evidence of a causal link but with a 25-year follow-up period it is one of the longest studies to detect this association.

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Novel Alzheimer’s treatment clears brain plaques with light and oxygen

An artist's impression of amyloid plaques forming in the brain, which scientists hope to tackle as a way of treating Alzheimer's

Research into what causes Alzheimer’s and how it might be treated involves a number of possibilities, but one scientists are continually coming back to is brain plaques playing a central role in driving the disease. It follows that researchers are investigating ways to destroy these plaques or prevent them from forming, and scientists at the University of Tokyo have come up with a novel approach to this problem involving injectable, oxygenated atoms that are activated by infrared light.

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New evidence links harmful oral bacteria with early Alzheimer’s signs

In a new study, increased volumes of harmful oral bacteria were associated with high levels of a toxic protein thought to be a major cause of neurodegeneration

The neurodegeneration associated with Alzheimer’s disease can often take 10 or 20 years before clinical signs of cognitive decline become apparent. Identifying these early preclinical stages of Alzheimer’s is still very much a challenge to researchers. One hypothesis, slowly building an intriguing body of evidence, suggests periodontal disease could be an early causal contributor to Alzheimer’s neurodegeneration.

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“Zinc finger” gene therapy tackles the toxic tangles of Alzheimer’s

An artist's depiction of amyloid plaques surrounded by tau tangles, both considered key pathological signs of Alzheimer's disease

There are a lot of unknowns when it comes to the way Alzheimer’s takes hold in the brain, but one area where researchers are focusing much of their attention is the development of toxic clumps of proteins in the brain. These harmful clusters are seen as key players in the cognitive decline associated with the disease, and scientists have now found that a single injection of a novel gene therapy may be able to prevent a significant portion of them from forming.

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New studies explore how gut microbiome affects Alzheimer’s and diabetes

The studies look at how gut bacteria is connected to neurodegenerative and whether the microbiome can be used to predict diabetes disease progression

Two new studies are offering yet more evidence the gut microbiome is deeply intertwined with our metabolic and brain health. One study offers some of the first experimental evidence to show a direct relationship between gut bacteria and cognitive changes in a mouse model of Alzheimer’s, while a second suggests microbial biomarkers in the gut could be used to predict the progression of prediabetes to type 2 diabetes years ahead of time.

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Ultrasound triggers brain’s waste disposal system in Alzheimer’s patients

Rashi Mehta led a research team at West Virginia University investigating targeted ultrasound as a potential treatment for Alzheimer's

Among the many moving parts that scientists suspect may play a role in Alzheimer’s disease is one known as the glymphatic system, which is thought to flush waste chemicals from the brain. A new study has demonstrated how this recently discovered system might be kicked into gear via ultrasound, with the technique proving effective in stimulating its activity in patients as part of early human trials.

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