Landmark study finds “significant” brain changes after mild COVID-19

A landmark imaging study has offered a unique insight into the effects of mild COVID-19 on the brain by investigating scans from hundreds of people taken before and after viral infection. The research indicates the impact of COVID-19 on the brain is bo… Continue reading Landmark study finds “significant” brain changes after mild COVID-19

Increased dementia risk in women linked to early menopause

Very early onset of menopause was linked to a 35 percent increased risk of developing dementia

New research presented at the American Heart Association’s Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Conference 2022 has found women who experience very early menopause are significantly more likely to develop dementia in later life.

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Age-related cognitive decline linked with buildup of iron in the brain

New research homes in on a mechanism that could explain how brain iron levels increase with age

Researchers at Northwestern Western have uncovered a mechanism they say contributes to the age-related accumulation of iron in the brain, a process some argue is a cause of cognitive decline. The study bolsters the hypothesis that reducing brain iron levels could combat neurodegenerative diseases such as Alzheimer’s.

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Brain tissue study sheds light on how exercise can fight dementia

Researchers have linked physical activity to higher levels of presynaptic proteins in the brain

A new post-mortem brain tissue study is offering clues as to how exercise in old age can improve brain health and prevent cognitive decline. The research found late-life physical activity was associated with higher levels of presynaptic proteins, molecules previously found to support healthy brain functions.

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Dementia-preventing nasal spray moves to human trials

A novel nasal spray combines a common antibiotic with a well-known antioxidant and human trials are set to begin soon

Scientists from Osaka City University are reporting successful preclinical tests of a novel nasal spray designed to prevent the neurodegeneration associated with dementia. The spray combines two cheap, pre-existing drugs and was found to improve cognitive function in several different mouse models of dementia.

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How gym junkie mice could inspire a new therapy for dementia

The researchers homed in on an exercise-induced protein called clusterin and suspect it has anti-inflammatory properties helping tamp down neuroinflammation and improving cognition

We know exercise is good for the brain, but we don’t know exactly how exercise improves brain health. A new Stanford study has homed in on a single anti-inflammatory protein that seems to increase in the blood with exercise and the findings could inspire new kinds of drugs that prevent neurodegeneration or cognitive decline.

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Refined peptide takes aim at root cause of Parkinson’s disease

Scientists have developed a novel peptide that can prevent misfolding proteins associated with Parkinson's disease

Misfolding alpha-synuclein (αS) proteins are considered key players in the development of Parkinson’s disease, giving rise to toxic clumps called Lewy bodies that kill off important brain cells. As such, a lot of research focuses on preventing this type of protein dysfunction, and scientists at the University of Bath have now made a breakthrough with the development of a finely engineered peptide, which produced “very exciting” results in early experiments.

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Study links Viagra to lower Alzheimer’s risk but experts have reservations

New research proposes Viagra could prevent the development of Alzheimer's disease

A new study published in the journal Nature Aging has identified an association between using Viagra, a popular erectile dysfunction drug, and reduced instances of Alzheimer’s disease. This is not the first time a beneficial link between Viagra and Alzheimer’s has been proposed but clinical trials will be necessary to explore causality.

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Long-term study links amateur boxing to earlier onset of dementia

Researchers found those older men who boxed when they were young were three times more likely to develop Alzheimer's-like cognitive impairments compared to men who did not box

Using data from an ongoing long-term health study spanning 35 years, researchers have found men who participated in amateur boxing in their youth are almost three times more likely to suffer from Alzheimer’s-like cognitive impairment in their senior years compared to those who did not box when young.

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New Alzheimer’s drug leads to brain swelling in one-third of patients

Aducanumab was controversially approved by the FDA in June despite an advisory panel recommending against its approval

A new study published in the journal JAMA Neurology is reporting more than one in three patients trialing the recently approved Alzheimer’s drug aducanumab experienced brain swelling side effects. The data is the first from the controversial drug’s Phase 3 trials to be peer-reviewed and published.

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