FDA approves very first drug shown to slow Alzheimer’s disease

While not a cure, Leqembi may offer suitable patients more time with loved ones and an extended quality of life

The first Alzheimer’s disease medication shown in trials to slow progression of the disease has been given full approval by the Food and Drug Administration (FDA), paving the way for its costly price tag to be covered by Medicare.

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Not enough sleep may cancel the benefits of exercise on brain health

Physical activity without more than six hours of shuteye a night may not be as effective as thought

Physical activity at any age has a broad range of health benefits. However, if you’re not getting enough sleep in middle age, exercise may not be providing enough to offset cognitive decline.

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More signs that resistance training protects brain from Alzheimer’s

Studies are increasingly linking the maintenance of muscle with brain health longevity

There’s a growing body of evidence that links muscle makeup to cognitive function, particularly in that it may be key to prolonging brain health as you age.

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Menopause treatment linked to increased risk of dementia

A large study has suggested there may be a link between taking menopausal hormone therapy and dementia risk

A large new study has suggested there may be a link between women’s use of hormone replacement therapy used to treat the symptoms of menopause and the risk of developing dementia.

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Molecule patches leaks in blood-brain barrier to prevent MS or Alzheimer’s

A new study has identified promising molecules that could help patch up leaks in the blood-brain barrier

Being the control center of the body, your brain needs strong security against circulating pathogens or toxins. The blood-brain barrier (BBB) performs this vital function, but it can become “leaky.” Now, scientists at Stanford have identified therapeutic molecules that could help patch it up, to potentially prevent neurological diseases.

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Self-administered smartphone speech app may spot Alzheimer’s early on

Researchers have developed a self-administered smartphone app that analyzes speech for the telltale signs of early dementia

Researchers have developed a self-administered smartphone app to screen for neurodegenerative conditions like Alzheimer’s disease and mild cognitive impairment by analyzing speech patterns. With subtle speech disturbances being an early indicator of these conditions, this may be an easy way to obtain a diagnosis quicker.

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Genetic mutation linked to delayed onset of rare Alzheimer’s

Researchers have identified a new genetic mutation in a Colombian man that stalled the symptoms of Alzheimer's for 20 years

Researchers have identified a Colombian man carrying a never-before-seen genetic mutation that protected him from the symptoms of a rare, inherited form of Alzheimer’s, characterized by a very early onset of cognitive decline, for 20 years. The discovery could lead to therapies that boost people’s resilience against the debilitating disease.

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Subset of brain immune cells identified, linked to cognition and memory

Researchers have identified a subset of microglia, the brain's immune cells, called ARG1+ microglia (shown here in yellow), surrounded by regular microglia (red)

A new study has discovered the important role that a subset of microglia, the brain’s immune cells, plays in early brain development, cognition and memory. The finding gives us a better understanding of how these cells work and could pave the way for new treatments for neurodegenerative conditions like Alzheimer’s disease.

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First map of “Commander complex” could help fight diseases, dementia

Multi-colored spirals on a black background

Using AI, researchers have created the first map of a group of proteins known as the Commander complex, which function as the body’s “postal workers.” The new understanding opens the door to new drugs and modalities for fighting everything from Alzheimer’s to infectious diseases to cancer.

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Protein size determines Alzheimer’s stage, may lead to earlier detection

In Alzheimer's disease, protein fibrils in the brain form plaques. The accumulation of such tangles leads to the death of nerve cells and a loss of cognitive performance

Testing for protein clumps in spinal fluid is the conventional way of detecting Alzheimer’s disease, but it doesn’t provide information about the disease’s stage. In a new study, researchers were able to stage the disease using atomic force microscopy to visualize the size and shape of these clumps, which may provide a way of detecting the debilitating disease earlier.

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