Newly discovered type of dementia may account for 20 percent of cases

Quadruple misfolded proteins, or QMP, refers to the presence of four separate kinds of toxic protein accumulations

A new study from the University of Kentucky has described a novel form of dementia characterized by the toxic accumulation of four different proteins in the brain. The research suggests many patients diagnosed with Alzheimer’s disease may be suffering from this different, and more complex, neurodegenerative condition.

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Synthetic immune cell rallies the troops to fight cancer

Immunotherapy is a promising potential treatment for cancer, but it still has kinks to iron out. In a new study from Yale, researchers have identified a “jamming signal” that cancer uses to hide from the immune system – and importantly, engineered a sy… Continue reading Synthetic immune cell rallies the troops to fight cancer

New Microscope Directly Images Protein Atoms

There’s an old joke that you can’t trust atoms — they make up everything. But until fairly recently, there was no real way to see individual atoms. You could infer things about them using X-ray crystallography or measure their pull on tiny probes using atomic force microscopes, but not take …read more

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Positive early Alzheimer’s trial results for repurposed cancer drug

A drug originally developed to treat leukemia, and approved for use in the United States in 2007, has shown promise for treating Alzheimer's

Encouraging results from a small Phase 2 human trial testing the effects of a cancer drug in treating Alzheimer’s disease have been published in the journal Annals of Neurology. The data suggests the drug is safe, well-tolerated and alters biomarkers associated with Alzheimer’s. A larger efficacy study is currently planned.

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Scientists identify two protein pieces of the cancer puzzle

How cancer develops is a complex puzzle, involving untold moving parts and chemical reactions. Now, scientists have found how two of these pieces work together to prevent cancer forming, which could unlock new types of cancer treatments.Continue Readin… Continue reading Scientists identify two protein pieces of the cancer puzzle

Antibody breakthrough promises new view of toxic Alzheimer’s proteins

Researchers have not had an accurate or easy way to detect amyloid oligomers, the protein accumulations smaller than the commonly known plaques – until now

An international team of scientists has designed a novel antibody that can accurately detect the toxic oligomers suspected to cause the neurodegeneration associated with Alzheimer’s disease. It’s hoped the breakthrough will lead to improved drug design and clinical testing by offering researchers a new way to measure these protein aggregations.

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Bacterial attack system hijacked and controlled with light

Some bacteria are known to inject toxins into host cells using a syringe-like appendage. Past research has found that we might be able to hijack that as a new drug delivery system, and now scientists from the Max Planck Institute have developed a way t… Continue reading Bacterial attack system hijacked and controlled with light

Cell-division helper protein identified as potential cancer target

Cell division is a crucial process in the body, but cancer cranks it into overdrive with often deadly results. Now, researchers from the University of Copenhagen have identified a protein that plays a key role in the process, meaning it could be a futu… Continue reading Cell-division helper protein identified as potential cancer target

“Peptide pills” breakthrough could open new avenue for oral drugs

Peptides do important work, and could be a largely untapped type of drug. The problem is they can’t be taken orally, because stomach acids destroy them before they can get into the bloodstream. Now, researchers at EPFL have developed a new method of te… Continue reading “Peptide pills” breakthrough could open new avenue for oral drugs

Potentially exploitable weakness found in bacteria’s outer armor

For bacteria, the first line of defense is the cell wall, which keeps toxins such as antibiotics out. Now, researchers have discovered a key mechanism that bacteria use to build their cell walls, which could present a new target in the ongoing quest to… Continue reading Potentially exploitable weakness found in bacteria’s outer armor