World-first gene therapy reverses Alzheimer’s memory loss in mice

Research into Alzheimer's-related memory loss has uncovered an exciting new breakthrough in the form of a world-first gene therapy

Scientists in Australia have made an exciting breakthrough in Alzheimer’s research, demonstrating what they describe as the first gene-therapy-based approach for treating advanced forms of the disease. Through experiments in mice, the team was able to show how activating a key enzyme in the brain can prevent the kind of memory loss associated with advanced forms of Alzheimer’s, and even reverse it.

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Alzheimer’s blood test detects early toxic proteins with 86% accuracy

A new blood test could one day aid in the early diagnosis of Alzheimer's

Alzheimer’s is a disease that can take hold in the brain long before symptoms, like memory and cognitive decline, become evident. This makes it a very tricky one to diagnose early in the piece, but a new breed of blood tests are emerging that could change the game in this regard. The latest centers on a new biomarker in the blood, which was shown to distinguish healthy patients from early asymptomatic Alzheimer’s patients with a high degree of accuracy.

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Brain activity signature catches schizophrenia before symptoms appear

A robust new study investigating brain activity patterns in schizophrenia patients and their siblings is suggesting a specific brain “signature” could detect the condition in subjects before clinical symptoms appear. The study also hypothesizes modulat… Continue reading Brain activity signature catches schizophrenia before symptoms appear

Brain-boosting protein raises prospect of exercise benefits in a pill

An intriguing new study from UC San Francisco scientists has identified a protein produced by the liver after exercise that could protect the brain from age-related cognitive decline. As well as helping explain the neuroprotective benefits of exercise,… Continue reading Brain-boosting protein raises prospect of exercise benefits in a pill

Single-gene treatment cures mice of Parkinson’s within three months

Mouse astrocytes (green) before reprogramming on the left, and on the right after being converted into neurons

While there are ways to alleviate some symptoms, there is currently no way to prevent or cure Parkinson’s disease, so the prospect of a one-off treatment that completely eliminates it is certainly an exciting one. While such a therapy remains a while off, scientists have demonstrated an exciting proof of concept in mice, whereby inhibiting a single gene as a one-time treatment eradicated the disease entirely, and kept it at bay for the remainder of their lives.

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The curious case of the man who can’t see numbers

Damaged brains have given us an incredible treasure trove of information to help us untangle the mysteries of the human mind. A tiny brain lesion can shift a person’s reality in bizarre and tragic ways, as anyone who’s read The Man Who Mistook His Wife… Continue reading The curious case of the man who can’t see numbers

Aerobic exercise shown to improve memory in those at risk of dementia

A 12-month study found aerobic exercise improves blood flow to parts of the brain linked with memory

The results of a year-long trial led by researchers at UT Southwestern have homed in on how aerobic exercise can improve memory in older subjects with mild cognitive impairment. The findings suggest it is never too late to start exercising as aerobic activity improves blood flow to regions of the brain associated with memory.

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Experimental chronic pain treatment looks to first human trials

A new study published in the journal EMBO Molecular Medicine describes the successful results of animal studies testing a novel experimental peptide designed to inhibit the receptors responsible for chronic neuropathic pain. The University of Copenhage… Continue reading Experimental chronic pain treatment looks to first human trials

Blue light lowers depression for concussion sufferers in early study

A small but promising study carried out at University of Arizona has uncovered some interesting possibilities around treatment for common concussion symptoms. The researchers found that by subjecting people with a mild brain injury to a dose of blue li… Continue reading Blue light lowers depression for concussion sufferers in early study

New research insights into celiac disease offer equal hope and concern

Two new studies are offering novel insights into celiac disease, the autoimmune disorder triggered by exposure to gluten. One study from University of Sheffield researchers is suggesting immune responses to gluten in celiac sufferers can lead to neurol… Continue reading New research insights into celiac disease offer equal hope and concern