Hackaday Prize and UCPLA Are Driving Assistive Technology Forward

Take a second to imagine all the people in your life. Your family, friends, coworkers. Your buddies down at the hackerspace, and anyone you chat with on IO and over the airwaves. Statistically speaking, one in four of these people has a disability of some kind, and needs help doing …read more

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Positive early Alzheimer’s trial results for repurposed cancer drug

A drug originally developed to treat leukemia, and approved for use in the United States in 2007, has shown promise for treating Alzheimer's

Encouraging results from a small Phase 2 human trial testing the effects of a cancer drug in treating Alzheimer’s disease have been published in the journal Annals of Neurology. The data suggests the drug is safe, well-tolerated and alters biomarkers associated with Alzheimer’s. A larger efficacy study is currently planned.

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Biomarker detects Alzheimer’s decades before symptoms appear

A protein released into the body as a result of neuronal damage could indicate the early stages of neurodegenerative diseases such as Alzheimer's and Huntington's over 20 years before symptoms appear

Two new studies, published in the journal The Lancet Neurology, are suggesting increasing levels of a particular brain protein, detected in blood and spinal fluid, could be the earliest sign of neurodegenerative diseases such as Alzheimer’s and Huntington’s.

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Continue reading Biomarker detects Alzheimer’s decades before symptoms appear

Biomarker detects Alzheimer’s decades before symptoms appear

A protein released into the body as a result of neuronal damage could indicate the early stages of neurodegenerative diseases such as Alzheimer's and Huntington's over 20 years before symptoms appear

Two new studies, published in the journal The Lancet Neurology, are suggesting increasing levels of a particular brain protein, detected in blood and spinal fluid, could be the earliest sign of neurodegenerative diseases such as Alzheimer’s and Huntington’s.

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Continue reading Biomarker detects Alzheimer’s decades before symptoms appear

Antibody breakthrough promises new view of toxic Alzheimer’s proteins

Researchers have not had an accurate or easy way to detect amyloid oligomers, the protein accumulations smaller than the commonly known plaques – until now

An international team of scientists has designed a novel antibody that can accurately detect the toxic oligomers suspected to cause the neurodegeneration associated with Alzheimer’s disease. It’s hoped the breakthrough will lead to improved drug design and clinical testing by offering researchers a new way to measure these protein aggregations.

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Aerobic exercise shown to improve memory in those at risk of dementia

A 12-month study found aerobic exercise improves blood flow to parts of the brain linked with memory

The results of a year-long trial led by researchers at UT Southwestern have homed in on how aerobic exercise can improve memory in older subjects with mild cognitive impairment. The findings suggest it is never too late to start exercising as aerobic activity improves blood flow to regions of the brain associated with memory.

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Elevated calcium in mitochondria linked to cell death in Alzheimer’s

A new study has uncovered a relationship between elevated levels of calcium ions in the mitochondria and cell death in Alzheimer's

There are many unknowns when it comes to the complex mechanisms underpinning Alzheimer’s disease, but research is continuing to shine a light on some of the key suspects. A new mouse study from Massachusetts General Hospital has for the first time established a connection between elevated levels of calcium in mitochondria and neuron death associated with the disease, offering a potential new target for efforts to slow its progression.

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New compound combats the metal ions and plaques linked to Alzheimer’s

A newly developed compound could attack various facets of Alzheimer's disease

While its exact causes are unknown, Alzheimer’s disease is commonly associated with clumps of toxic amyloid plaques in the brain, and researchers are continuing to understand the different components that help them take shape. Scientists at the University of Illinois at Urbana-Champaign have developed a new compound that attacks a number of the key players in the formation of amyloid plaques, significantly decreasing the level of plaques and reducing inflammation in the brain.

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3D brain model offers new evidence linking Alzheimer’s to herpes virus

The 3D brain tissue model shows amyloid beta fibrils (in red), and herpes-infected neurons (in green)

New evidence has been published in the journal Science Advances, adding weight to the link between Alzheimer’s disease and the common herpes virus. The Tufts University study, using a 3D bioengineered brain model, demonstrated how a herpes infection can induce a number of Alzheimer’s features, including neuroinflammation and amyloid plaques.

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New study shows how ultrasound technique can treat Alzheimer’s disease

The research investigates how the blood-brain barrier, composed of endothelial cells (imaged above), can be disrupted by focused ultrasound and potentially help treat Alzheimer's disease

A new study led by Australian researchers is offering further insight into how a novel ultrasound technique could help treat Alzheimer’s disease. The findings describe how focused ultrasound can weaken the blood-brain barrier in brain cells from Alzheimer’s patients, potentially improving the uptake of drugs designed to treat the disease.

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