Pupil-tracking smartphone app looks to catch early-stage Alzheimer’s

Using the selfie camera and the front-facing near-infrared camera, a smartphone app could assess cognitive condition

A prototype smartphone app has been developed to screen for the very earliest stages of Alzheimer’s disease. The app tracks minute changes in a person’s pupil size, which previous research has shown can indicate pre-clinical neurological disease.

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Trial finds insulin nasal spray may slow age-related cognitive decline

The results of a small Phase 2 clinical trial offers promising signs that daily doses of an insulin nasal spray could be used to slow age-related cognitive decline. The trial found the treatment to be effective in elderly subjects both with and without… Continue reading Trial finds insulin nasal spray may slow age-related cognitive decline

New study may explain why apathy is the first symptom of Alzheimer’s

New research hypothesizes degeneration in a brain region called the nucleus accumbens could trigger apathy, the earliest psychiatric sign of Alzheimer's disease

Compelling new research from the Indiana University School of Medicine has homed in on a degenerative mechanism that could explain why symptoms such as apathy are the first signs of Alzheimer’s disease. The findings suggest disrupting this process could slow the progression of Alzheimer’s-related dementia.

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New hypothesis argues leaky blood-brain barrier triggers Alzheimer’s

A new hypothesis proposes fatty molecules in the blood stream invade the brain through a leaky blood brain barrier and this processes triggers Alzheimer's disease

A new article in the Journal of Alzheimer’s Disease Reports has proposed a novel hypothesis for the cause of Alzheimer’s disease. The article argues Alzheimer’s is caused by a damaged blood-brain barrier allowing fatty molecules known as lipids to invade the brain and trigger a cascade of events that result in neurodegeneration and cognitive decline.

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Alzheimer’s-preventing nasal spray targets novel brain mechanism

A nasal spray has been developed to inhibit a brain mechanism hypothesized to be an early driver of Alzheimer's disease

An international team of researchers has reported on the successful preclinical tests of a novel nasal spray developed to prevent neurodegeneration associated with Alzheimer’s disease. The treatment was effective at reversing the pathological signs of Alzheimer’s in mouse models and the researchers are looking to start human tests in two years.

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Landmark study finds 42 new genetic risk factors for Alzheimer’s disease

New research has discovered more than 40 genetic regions previously not associated with Alzheimer's disease risk

A milestone study involving hundreds of scientists from around the world has identified 75 genomic regions associated with Alzheimer’s disease. A number of the newly discovered genetic pathways play a role in inflammation, adding weight to a growing hypothesis immune dysfunction can drive disease progression. Plus, the researchers raise the possibility of developing an Alzheimer’s genetic risk test to predict those most likely to develop the neurodegenerative condition.

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Long COVID study indicates “something concerning is happening”

Two new studies are reporting on an ongoing long COVID research project investigating the persistent effects of COVID-19 on cognition in the months after acute disease. The University of Cambridge-led research found many long COVID patients are experie… Continue reading Long COVID study indicates “something concerning is happening”

Excessive daytime napping could be early sign of Alzheimer’s disease

Napping for more than one hour or more than once a day has been linked to Alzheimer's

Napping for longer than one hour or several times a day could be an early sign of Alzheimer’s disease according to new research. It’s suggested excessive daytime napping shares a bidirectional relationship with cognitive decline, both reflecting and shaping changes in the brain.

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“Elite sleeper” gene study offers hope for novel dementia treatment

New research indicates people with the ability to sleep as little as four hours a night and remain healthy may harbor gene variants that can slow neurodegeneration

Are you one of those lucky people who seem to be able to thrive on between four and six hours of sleep per night? You may be what UC San Francisco researchers have dubbed an “elite sleeper,” and a new study reports the same genes associated with healthy short sleep patterns may also slow the onset of neurodegenerative diseases such as Alzheimer’s.

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Remote indigenous Amazon tribe has lowest dementia rates in the world

An isolated tribe in the Bolivian Amazon was previously also found to have the healthiest arteries of any population ever studied

Researchers working with remote indigenous populations in the Bolivian Amazon have found the communities experience extraordinarily low rates of dementia. The new study follows on from prior findings reporting the same groups display almost no cases of age-related heart disease.

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