New hypothesis argues leaky blood-brain barrier triggers Alzheimer’s

A new hypothesis proposes fatty molecules in the blood stream invade the brain through a leaky blood brain barrier and this processes triggers Alzheimer's disease

A new article in the Journal of Alzheimer’s Disease Reports has proposed a novel hypothesis for the cause of Alzheimer’s disease. The article argues Alzheimer’s is caused by a damaged blood-brain barrier allowing fatty molecules known as lipids to invade the brain and trigger a cascade of events that result in neurodegeneration and cognitive decline.

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mRNA vaccine boosts cancer immunotherapy in early human trial data

Preliminary data presented at the American Association of Cancer Research Annual Meeting has provided promising signs for a new cancer treatment that combines immunotherapy with an mRNA vaccine. The first reports from the Phase 1 human trial indicate t… Continue reading mRNA vaccine boosts cancer immunotherapy in early human trial data

Risk of serious blood clot events spike in the months after COVID-19

New observational research out of Sweden has tracked more than one million COVID-19 cases for months after their acute illness in order to determine how the disease influences subsequent risk of blood clots. The findings indicate COVID-19 significantly… Continue reading Risk of serious blood clot events spike in the months after COVID-19

Study suggests causal link between insomnia and high blood sugar

Poor or disrupted sleep has long been associated with a variety of negative health outcomes, from obesity and heart disease to dementia and depression. But there is an ongoing debate amongst researchers over the causal direction of these associations.C… Continue reading Study suggests causal link between insomnia and high blood sugar

World-first massive MRI study charts brain changes from birth to death

More than 100,000 MRI scans were used to develop the first chart measuring normal brain changes over a human lifetime

Hundreds of scientists around the globe have shared data to create the world’s first brain growth chart. The project incorporated MRI scans from subjects of all ages to offer a unique portrait of how our brains change over the course of a lifetime.

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Alzheimer’s-preventing nasal spray targets novel brain mechanism

A nasal spray has been developed to inhibit a brain mechanism hypothesized to be an early driver of Alzheimer's disease

An international team of researchers has reported on the successful preclinical tests of a novel nasal spray developed to prevent neurodegeneration associated with Alzheimer’s disease. The treatment was effective at reversing the pathological signs of Alzheimer’s in mouse models and the researchers are looking to start human tests in two years.

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FDA pulls COVID antibody therapy as BA.2 variant becomes dominant in US

New modeling from the Centers for Disease Control and Prevention (CDC) estimates the BA.2 Omicron variant is now dominant in the United States. In related news, the Food and Drug Administration (FDA) has withdrawn its emergency use authorization for th… Continue reading FDA pulls COVID antibody therapy as BA.2 variant becomes dominant in US

Diabetes successfully treated using ultrasound in preclinical study

Promising new research has raised the possibility of treating type 2 diabetes without drugs. Across three different animal models researchers have demonstrated how short bursts of ultrasound targeted at specific clusters of nerves in the liver can effe… Continue reading Diabetes successfully treated using ultrasound in preclinical study

Spot goes to Pompeii: Why a robot dog is patrolling ancient ruins

Boston Dynamics’ robot dog Spot has been tasked with a new job – patrolling the ancient ruins of Pompeii. The robot will be used to inspect the site for safety issues and record structural changes over time to better manage the historic ruins.Continue … Continue reading Spot goes to Pompeii: Why a robot dog is patrolling ancient ruins

Landmark study finds 42 new genetic risk factors for Alzheimer’s disease

New research has discovered more than 40 genetic regions previously not associated with Alzheimer's disease risk

A milestone study involving hundreds of scientists from around the world has identified 75 genomic regions associated with Alzheimer’s disease. A number of the newly discovered genetic pathways play a role in inflammation, adding weight to a growing hypothesis immune dysfunction can drive disease progression. Plus, the researchers raise the possibility of developing an Alzheimer’s genetic risk test to predict those most likely to develop the neurodegenerative condition.

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