Discovery of amyloid hairpin structure hints at vaccine for Alzheimer’s

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Though there is so much to learn about the way Alzheimer’s develops in the human brain, amyloid beta proteins have long been implicated in its advance. A new study has uncovered a previously unknown hairpin-like structure within this protein that proved critical to an antibody response seen in mice, with an engineered version of the protein fragment also laying the groundwork for a vaccine against the disease in humans.

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Discovery of amyloid hairpin structure hints at vaccine for Alzheimer’s

null

Though there is so much to learn about the way Alzheimer’s develops in the human brain, amyloid beta proteins have long been implicated in its advance. A new study has uncovered a previously unknown hairpin-like structure within this protein that proved critical to an antibody response seen in mice, with an engineered version of the protein fragment also laying the groundwork for a vaccine against the disease in humans.

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Continue reading Discovery of amyloid hairpin structure hints at vaccine for Alzheimer’s

Study reveals how COVID-19 can directly damage brain cells

New research published in the journal Nature Neuroscience is the first to demonstrate how the SARS-CoV-2 virus can directly damage cells in the brain. An international group of scientists found vascular cells that comprise the blood-brain barrier can b… Continue reading Study reveals how COVID-19 can directly damage brain cells

New evidence shows how viral infections could promote Alzheimer’s

The lab-based research found certain viral molecules could enhance the aggregation of toxic proteins linked with several neurodegenerative diseases

Building on a growing body of evidence linking viral infections with neurodegenerative disease, a new study published in Nature Communications has demonstrated how certain molecules on the surfaces of viruses can promote the aggregation of toxic proteins associated with diseases such as Alzheimer’s and Parkinson’s.

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Optimal blood pressure in early adulthood slows the brain’s aging process

Keeping blood pressure to optimal levels might be key to keeping our brains young and healthy, according to new research

The interplay between high blood pressure and brain health is one scientists continue to shed new light on, with studies increasingly linking hypertension to a decline in cognitive function later in life. New research has drilled into the details around when exactly this relationship begins to take shape, finding that it not only begins earlier than suspected, but that even those with blood pressure at the higher end of the normal recommended range can be at risk of premature brain aging.

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Common diuretic pill offers clues to new Alzheimer’s treatment

The research began by looking for existing FDA-approved drugs with the capacity to target genes related to Alzheimer's disease risk

Researchers on the hunt for a pre-approved medicine that can be repurposed to treat Alzheimer’s disease have found promising signs of effectiveness in a 50-year-old generic drug commonly used as a diuretic. Through a variety of animal studies and real-world investigations, the new study indicates exposure to the common drug could significantly reduce a person’s risk of developing Alzheimer’s.

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“Harbinger” molecules could predict dementia up to 5 years in advance

Red blood cells in vein or artery, flow inside inside a living organism. 3d rendering

Earlier detection of dementia could open up far more effective ways to treat and manage the condition, and one place scientists are increasingly turning to for warning signs is the blood. A new study has further broadened the possibilities in this area, pinpointing a set of molecules the authors describe as a “harbinger” of the condition two to five years ahead of onset, and may even provide new targets for advanced therapies.

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Missing link between severe COVID-19 and Alzheimer’s disease discovered

The gene variant plays a role in heightened inflammatory responses influencing both Alzheimer's disease and severe COVID-19

Early in the pandemic researchers saw disproportionately high rates of dementia patients suffering from severe COVID-19. A common hypothesis was that memory impairments associated with neurodegeneration affect a person’s ability to consistently follow infection control measures such as social distancing and mask wearing. But a new study led by scientists from University College London is proposing a key gene variant, known to heighten one’s risk for Alzheimer’s, stimulates the body’s inflammatory responses and can lead to greater susceptibility to severe COVID-19.

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Cancer drug restores blood-brain barrier to reverse Alzheimer’s in mice

Preserving the blood-brain barrier might prove to be an effective way of preventing the onset of Alzheimer's disease

As researchers continue to search for the causes behind Alzheimer’s disease and age-related dementia, one possibility is that a leaky blood-brain barrier could have a role to play, allowing for the easy passage of harmful proteins. A new study has explored how this defense might be shored up through the use of an existing anti-cancer drug, with the authors demonstrating some promising results around the reversal of cognitive decline in mice.

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Landmark study presents evidence Alzheimer’s disease begins in the liver

Using a newly developed preclinical model, new research demonstrates how toxic amyloid proteins are produced in the liver and then travel to the brain

An impressive new study is presenting robust evidence showing the toxic proteins thought to be the cause of Alzheimer’s disease may be produced in the liver and travel through the blood before landing in the brain causing neuron damage.

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Continue reading Landmark study presents evidence Alzheimer’s disease begins in the liver