Optogenetics for 100 Euros

Larval zebrafish, Drosophila (fruit fly), and Caenorhabditis elegans (roundworm) have become key model organisms in modern neuroscience due to their low maintenance costs and easy sharing of genetic strains across labs. However, the purchase of a commercial solution for experiments using these organisms can be quite costly. Enter FlyPi: a low-cost and modular open-source alternative to commercially available options for optogenetic experimentation.

One of the things that larval zebrafish, fruit flies, and roundworms have in common is that scientists can monitor them individually or in groups in a behavioural arena while controlling the activity of select neurons using optogenetic (light-based) …read more

Continue reading Optogenetics for 100 Euros

Optogenetics for 100 Euros

Larval zebrafish, Drosophila (fruit fly), and Caenorhabditis elegans (roundworm) have become key model organisms in modern neuroscience due to their low maintenance costs and easy sharing of genetic strains across labs. However, the purchase of a commercial solution for experiments using these organisms can be quite costly. Enter FlyPi: a low-cost and modular open-source alternative to commercially available options for optogenetic experimentation.

One of the things that larval zebrafish, fruit flies, and roundworms have in common is that scientists can monitor them individually or in groups in a behavioural arena while controlling the activity of select neurons using optogenetic (light-based) …read more

Continue reading Optogenetics for 100 Euros

The Quest for Mice With Frickin’ Laser Beams (Pointed At Their Brains), Building A Laser Controller

[Scott Harden] is working on a research project involving optogenetics. From what we were able to piece together optogenetics is like this: someone genetically modifies a mouse to have cell behaviors which can activated by light sensitive proteins. The mice then have a frikin’ lasers mounted on their heads, but pointing inwards towards their brains not out towards Mr. Bond’s.

Naturally, to make any guesses about the resulting output behavior from the mouse the input light has to be very controlled and exact. [Scott] had a laser and he had a driver, but he didn’t have a controller to fire …read more

Continue reading The Quest for Mice With Frickin’ Laser Beams (Pointed At Their Brains), Building A Laser Controller