Nasal Alzheimer’s drug effective regardless of brain plaque levels

Researchers have found that a drug, delivered through the nose, effectively reduced brain inflammation in mice with Alzheimer's disease

Researchers have found that an intranasal immunotherapy drug, currently being tested as a treatment for multiple sclerosis, reduced brain inflammation and improved cognition in mice with Alzheimer’s disease, independent of the amount of beta-amyloid plaques present. They say the treatment could benefit people in the later stages of the disease.

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Vaccines to prevent fentanyl, heroin overdose close to human trials

Researchers are expected to begin human clinical trials in early 2024 to test the safety and efficacy of vaccines to prevent heroin and fentanyl overdoses. While there is still a way to go, if approved, the vaccines could revolutionize the treatment of… Continue reading Vaccines to prevent fentanyl, heroin overdose close to human trials

Human antibody proves a potent treatment for opioid overdose

Researchers have developed a human antibody that targets the opioid fentanyl and its derivatives, blocking the drug’s effects and reversing overdose better than currently available treatments. With clinical trials pending, the novel antibody therapy co… Continue reading Human antibody proves a potent treatment for opioid overdose

First-of-its-kind cancer drug targets mechanism that causes metastasis

Metastatic cancer accounts for up to 90% of all cancer deaths in the US annually. But with researchers developing a first-of-its-kind drug that inhibits the process by which cancer cells spread around the body, it’s hoped that this number will soon go … Continue reading First-of-its-kind cancer drug targets mechanism that causes metastasis

Humans may soon grow new teeth, with promising drug trial set

Some sharks get a new set of teeth every few weeks, while crocodiles can go through thousands of chompers in their long lifetimes. Yet the ability to endlessly replace our pearly whites is something that’s eluded us and nearly all other mammals. By the… Continue reading Humans may soon grow new teeth, with promising drug trial set

Molecular discovery may mean new treatments for rheumatoid arthritis

Injecting antibodies from a healthy person into someone suffering from rheumatoid arthritis can reduce inflammation and slow bone degeneration, but how this occurs has remained largely unknown until now. Researchers have uncovered the molecular pathway… Continue reading Molecular discovery may mean new treatments for rheumatoid arthritis

Trial drug shown to significantly slow early Alzheimer’s decline

The drug donanemab, which destroys the amyloid beta plaques that cause Alzheimer's disease, was the subject of a Phase 3 clinical trial

A Phase 3 clinical trial of the drug donanemab has shown it can significantly slow cognitive and functional decline in people with early-stage Alzheimer’s disease, compared with existing treatments.

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New study challenges decades-long understanding of our immune system

Researchers have discovered new information about how the body’s immune system works, simultaneously calling into question decades of understanding about the process of antibody-mediated immunity and opening the door for advancements in immunological t… Continue reading New study challenges decades-long understanding of our immune system

Sugar-coated antibodies cross blood-brain barrier to fight Alzheimer’s

The blood-brain barrier is a network of tightly packed tissues and blood vessels meant to keep harmful substances out, but it can interfere with helpful treatments as well

In the quest to combat Alzheimer’s disease, researchers have been hopeful about the use of antibodies to destroy peptides in the brain that cause damaging tangles and plaque buildups. So far though, such treatments have been unsuccessful. Postulating that the issue had to do with the antibodies getting blocked by the blood-brain barrier, scientists have found a way to sneak them into the brains of mice afflicted with the disease, and have seen encouraging results.

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Continue reading Sugar-coated antibodies cross blood-brain barrier to fight Alzheimer’s

Light therapy could ease side effects for cancer sufferers

Light-activated antibody therapy could pave the way for new acutely targeted treatment of cancer cells. Scientists at the University of East Anglia in the UK have successfully engineered antibody fragments that are activated by a specific UV light wave… Continue reading Light therapy could ease side effects for cancer sufferers