Collaborate Disseminate
Messenger RNA (mRNA) contains the instructions that direct a cell to make a specific protein using its built-in machinery. Many will be aware of mRNA because of its association with the COVID-19 vaccine. But mRNA has potential uses far beyond that, inc… Continue reading Engineered mRNA turns your body into a drug-making biofactory
Glioblastoma is one of the most deadly cancers, with few treatment options available. Now, a small human clinical trial has demonstrated an mRNA vaccine that quickly rallies the immune system to fight off the tumors, with promising results.Continue Rea… Continue reading mRNA vaccine tackles deadly brain cancer in human trial
One of the biggest challenges researchers face is making injectable medicines into versions that can be taken orally. Oral medications usually fail because they can’t withstand the harsh environment of the gut, which leads to poor bioavailability – a drug’s ability to be absorbed and exert a therapeutic effect on the body.
Tags: RNA, gene therapy, King’s College London
Continue reading Cow’s milk particles unlock one of medicine’s most challenging puzzles
A man that police caught taking 217 doses of COVID vaccine has offered himself up to researchers for a study looking into what happens to the immune system after so many doses. The results offer surprising insight into these new mRNA vaccines.Continue … Continue reading What happened to the guy who had 217 COVID vaccinations
Our bodies are home to trillions of microbes, including bacteria, viruses, fungi, and a whole host of others. Now, Stanford scientists have discovered an entirely new class of biological entities inside us, which they’ve ominously named “Obelisks.”Cont… Continue reading Completely new type of “biological entity” discovered in our bodies
Inspired by a creature from Greek mythology, researchers have created a ‘two-headed’ drug that prevents the production of the toxic protein linked to Parkinson’s disease before destroying the RNA machinery that makes it. The novel drug may be a way of slowing or even stopping the disease’s progression.
Tags: Parkinson’s Disease, RNA, Protein, Drug, Scripps Research Institute
Continue reading Novel ‘Chimera’ drug targets the ‘undruggable’ Parkinson’s protein
Moderna has announced the results of a Phase 2b trial investigating its mRNA treatment for skin cancer, and it continues a streak of promising news. When paired with an immunotherapy, the treatment significantly reduced the risks of recurrence, metasta… Continue reading mRNA skin cancer therapy halves risk of death in clinical trial
Researchers have discovered that mice possess a natural form of gene therapy, a non-coding RNA that can sidestep genetic mutations. They were able to engineer a programmable version that recognized specific genetic mutations and might be used to treat … Continue reading Mice have innate gene therapy agent to sidestep mutations, study finds
Researchers have discovered that a chemical modification to the synthetic messenger RNA used in therapeutics can cause the cell’s machinery to misread its instructions and result in unintended immune responses. Importantly, they’ve also discovered a so… Continue reading mRNA mod responsible for off-target effects identified & fixed
Researchers have conducted the first human trials of a new drug, lepodisiran, and found that a single injection reduced lipoprotein(a) – a ‘bad’ cholesterol with a genetic basis – to undetectable levels for almost a year. It has the potential to elimin… Continue reading One-dose drug reduced genetic bad cholesterol by 94% for almost a year