Fluorescence Microcope on a Hacker’s Budget

Some of biology’s most visually striking images come from fluorescence microscopes. Their brilliant colors on black look like a neon sign from an empty highway. A brand new fluorescence microscope is beyond a hacker’s budget and even beyond some labs’, but there are ways to upgrade an entry-level scope for …read more

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Open Source Biological Gear For the Masses

At the risk of putting too fine a point on it, Hackaday exists because people are out there building and documenting open source gadgets. If the person who built a particular gizmo is willing to show the world how they did it, consider us interested. Since you’re reading this, we’ll assume you are as well. Over the years, this mentality has been spreading out from the relatively niche hacker community into the greater engineering world, and we couldn’t be happier.

Case in point, the Poseidon project created at the California Institute of Technology. Developed by students [Sina Booeshaghi], [Eduardo Beltrame], …read more

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3D Printed Microscope Stage Offers Precise Movement

3D printing isn’t something you would usually associate with a high precision device, but this one shows that it can be used to create rather intricate things when needed. The Openflexure is a microscope stage that offers a mechanical stage that can be maneuvered precisely. The optics can be swapped out so it uses anything from a webcam to a very high-powered 100x magnification lens, but still move the stage smoothly and precisely. It can be driven by turning a knob or by three small motors. The plan is that the motors will eventually be driven by the software that …read more

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Deep Discounts Yield Deep Reverse Engineering of Biotech Hardware

Hitting the electronic surplus shop is probably old hat to most of our readership. Somewhere, everyone’s got that little festering pile of hardware they’re definitely going to use some day. An old fax is one thing, but how would your partner feel if you took home an entire pallet-sized gene sequencing rig? Our friend [kaspar] sent along an interesting note that the folks at Swiss hackerspace Hackteria got their hands on an Illumina HiSeq 2000 last year (see funny “look what we got!” photo at top) and have generated a huge amount of open documentation about whats inside and how …read more

Continue reading Deep Discounts Yield Deep Reverse Engineering of Biotech Hardware

Deep Discounts Yield Deep Reverse Engineering of Biotech Hardware

Hitting the electronic surplus shop is probably old hat to most of our readership. Somewhere, everyone’s got that little festering pile of hardware they’re definitely going to use some day. An old fax is one thing, but how would your partner feel if you took home an entire pallet-sized gene sequencing rig? Our friend [kaspar] sent along an interesting note that the folks at Swiss hackerspace Hackteria got their hands on an Illumina HiSeq 2000 last year (see funny “look what we got!” photo at top) and have generated a huge amount of open documentation about whats inside and how …read more

Continue reading Deep Discounts Yield Deep Reverse Engineering of Biotech Hardware

See Cells In A New Light With A DIY Fluorescence Microscope

Ever since a Dutch businessman peered into the microscopic world through his brass and glass contraption in the 1600s, microscopy has had a long, rich history of DIY innovation. This DIY fluorescence microscope is another step along that DIY path that might just open up a powerful imaging technique to amateur scientists and biohackers.

In fluorescence microscopy, cells are treated with various fluorescent dyes that can be excited with light at one wavelength and emit light at another. But as [Jonathan Bumstead] points out, fluorescence microscopes are generally priced out of the range of biohackers. His homebrew scope levels the …read more

Continue reading See Cells In A New Light With A DIY Fluorescence Microscope

See Cells In A New Light With A DIY Fluorescence Microscope

Ever since a Dutch businessman peered into the microscopic world through his brass and glass contraption in the 1600s, microscopy has had a long, rich history of DIY innovation. This DIY fluorescence microscope is another step along that DIY path that might just open up a powerful imaging technique to amateur scientists and biohackers.

In fluorescence microscopy, cells are treated with various fluorescent dyes that can be excited with light at one wavelength and emit light at another. But as [Jonathan Bumstead] points out, fluorescence microscopes are generally priced out of the range of biohackers. His homebrew scope levels the …read more

Continue reading See Cells In A New Light With A DIY Fluorescence Microscope

Arduino Provides Hands-Free Focus for Digital Inspection Scope

With surface-mount technology pushing the size of components ever smaller, even the most eagle-eyed among us needs some kind of optical assistance to do PCB work. Lots of microscopes have digital cameras too, which can be a big help – unless the camera fights you.

Faced With a camera whose idea of autofocus targets on didn’t quite coincide with his, [Scott M. Baker] took matters into his own hands – foot, actually – by replacing mouse inputs to the camera with an outboard controller. His particular camera’s autofocus can be turned off, but only via mouse clicks on the camera’s …read more

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Replace your Calipers with a Microscope and Image Analysis

Getting a good measurement is a matter of using the right tool for the job. A tape measure and a caliper are both useful tools, but they’re hardly interchangeable for every task. Some jobs call for a hands-off, indirect way to measure small distances, which is where this image analysis measuring technique can come in handy.

Although it appears [Saulius Lukse] purpose-built this rig, which consists of a microscopic lens on a digital camera mounted to the Z-axis of a small CNC machine, we suspect that anything capable of accurately and smoothly transitioning a camera vertically could be used. The …read more

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Wireless Ring Light For SMD Microscope

When [Felix Rusu], maker of the popular Moteino boards which started life as wireless Arduino compatibles, says he’s made a wireless ring light for his SMD microscope, we redirect our keystrokes to have a look. Of course, it’s a bit of wordplay on his part. What he’s done is made a new ring light which uses a battery instead of having annoying wires go to a wall wart. That’s important for someone who spends so much time hunched over the microscope. Oh, and he’s built the ring light on a rather nice looking SMD board.

The board offers a few …read more

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